Trabecular bone score (TBS) as a complementary tool for assessing vertebral fractures and spinal deformity in children and adolescents with osteogenesis imperfecta
Authors' conclusion
TBS has a close correlation with bone mineral density in children and adolescents with OI. In patients without densitometric osteoporosis, the Z-score of TBS is more effective than that of bone mineral density in assessing VCFs and spinal deformity, highlighting the potential of TBS in evaluating the risk of VCFs and monitoring the progression of spinal deformity.
Study context
- Population
- Children and adolescents with osteogenesis imperfecta (OI)
- Participants
- 153 children
- Exposure
- TBS Z-score vs lumbar spine areal bone mineral density (aBMD) Z-score for identifying vertebral compression fractures (VCFs)
- Outcome
- Accuracy (AUC) of TBS and aBMD for identifying vertebral compression fractures (VCFs) on lateral thoracolumbar films
Main finding
As reported in the abstract
| Group | Value | AUC |
|---|---|---|
| TBS Z-score | 0.667 | 0.667 |
| Lumbar spine aBMD Z-score | 0.666 | 0.666 |
Value
AUC
- TBS Z-score vs Lumbar spine aBMD Z-score: P > 0.05 — TBS Z-score as effective as lumbar spine aBMD Z-score
Observational data: associations, not effects.
Further findings
| Outcome | TBS Z-score | Lumbar spine aBMD Z-score | P value |
|---|---|---|---|
| Discrimination of VCFs (AUC), subgroup without densitometric osteoporosisSuperior discriminative power with TBS Z-score | P < 0.05 | ||
| AUC | 0.719 | 0.545 |
Correlation of TBS Z-score with spine deformity index (SDI), subgroup without densitometric osteoporosis
- TBS Z-score vs SDI (r); lumbar spine aBMD Z-score not correlated
- r = - 0.358, P < 0.05
Correlation of TBS Z-score with age
- TBS Z-score vs age (r)
- r = - 0.435, P < 0.001
Correlation of TBS Z-score with aBMD Z-score (lumbar spine and femoral neck)
- Positive correlation, persisting after adjustment for confounders
- both P < 0.01
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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