Bone Health Index: a fracture risk assessment tool in children with osteogenesis imperfecta
Main finding · Incident fracture within two yearsResult — go to the resultOdds ratio 5.26 95% CI 2.4–11.1Authors' conclusion
Our study indicates that lower BHI SDS values are associated with increased fracture risk in children with classical OI. In the available DXA subgroup, BHI demonstrated stronger discriminatory performance than DXA-derived measures.
Study context
- Population
- Children with classical Osteogenesis Imperfecta (OI) followed at Great Ormond Street Hospital (London, UK)cohort of over 277
- Exposure
- Bone Health Index (BHI) SDS vs DXA bone mineral density (BMD) Z-score vs BMAD Z-score for prediction of incident fracture
- BHI SDSn = 123
- DXA BMD Z-scoren = 47
- Outcome
- Incident fracture
- Follow-up
- Within two years
Methodological detailssingle-centre
- Single-centre
Main finding
Incident fracture within two years
Odds ratio
5.26
95% CI 2.4–11.1
P < 0.001
By group
BHI SDS
0.84
AUC
DXA BMD Z-score
0.60
AUC
BMAD Z-score
0.51
AUC
BHI SDS
OR 5.26 (95% CI 2.4–11.1); P < 0.001
Per 1-SD decrease in BHI SDS, as printed
As reported in the abstract
Observational data: associations, not effects.
Original publication
Bone Health Index: a fracture risk assessment tool in children with osteogenesis imperfecta. J Clin Endocrinol Metab. Published 13 August 2026. doi:10.
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