Large scale proteomic analyses of high-resolution peripheral quantitative computed tomography (HR-pQCT)-derived bone loss at the radius and tibia in older men
Authors' conclusion
These data are among the first to examine the serum proteins associated with longitudinal bone loss, and they implicate several underlying biological processes that might be related.
Study context
- Population
- Older men (mean age 84 yr); distal radial and tibial bone loss assessed with HR-pQCT over ≈6 yr
- Outcome
- Serum proteins associated with rates of distal radial and tibial bone loss (HR-pQCT)
- Follow-up
- ≈6 yr
Methodological detailslarge-scale discovery proteomics, aptamer-based assays (SomaLogic)
- Large-scale discovery proteomics
- Aptamer-based assays (SomaLogic)
Main finding
As reported in the abstract
Serum proteins associated with incident bone loss
- Proteins associated with incident bone loss (stringent statistical criteria)
- 22
Observational data: associations, not effects.
Original publication
Large scale proteomic analyses of HR-pQCT-derived bone loss at the radius and tibia in older men. J Bone Miner Res. Published 13 August 2026. doi:10.
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