Reduced Gastric Mucosal Innervation in Obesity: A Biomarker Predicting Remission of Diabetes After Bariatric Surgery
Authors' conclusion
Gastric mucosal innervation was significantly reduced by the synergistic effects of obesity and diabetes. GMID could serve as a potential biomarker for predicting diabetes remission following bariatric surgery.
Study context
- Population
- Patients with obesity (30 with and 30 without T2D) undergoing sleeve gastrectomy and healthy controls
- Participants
- 60 vs 15
- Exposure
- Patients with obesity undergoing sleeve gastrectomy vs healthy controls
- Obesityn = 60
- Healthy controlsn = 15reference
- Outcome
- Gastric mucosal innervation density (GMID) at the antrum, protein gene product 9.5 immunostaining, stereology-based morphometry
Main finding
As reported in the abstract
GMID
P < 0.001
Observational data: associations, not effects.
Further findings
With diabetes vs Without diabetes
GMID, obesity with vs without diabetes · further reduction with diabetes
P < 0.001
Remission vs No remission
GMID by diabetes remission after surgery · 1 year post surgery · higher with remission
P = 0.012
- Gastric mucosal innervation density (GMID) by diabetes remission after surgery — Patients achieving diabetes remission
- 19
Associations of GMID
- GMID significantly associated with BMI and glycemic parameters (fasting blood glucose, HbA1c) in multilinear regression
GMID by diabetes remission after surgery · 1 year post surgery
- GMID remained an independent predictor of diabetes remission in multivariable logistic regression
Original publication
Reduced Gastric Mucosal Innervation in Obesity: A Biomarker Predicting Remission of Diabetes After Bariatric Surgery. Obesity (Silver Spring). Published 2 September 2025. doi:10.
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