Racial differences in measures of glycemia in the Vitamin D and Type 2 Diabetes (D2d) Study: a secondary analysis of a randomized trial
Authors' conclusion
Use of additional testing beyond A1c to screen for diabetes may better stratify diabetes risk in the diverse US population.
Study context
- Population
- Persons at risk of diabetes with concurrently measured HbA1c and oral glucose tolerance test (OGTT), 22 US clinical sites; subset with high-risk prediabetes followed longitudinally2,154 followed
- Participants
- 1,016 / 2,658 / 193
- Comparison
- Black and Asian vs white participants
- Blackn = 1,016
- Whiten = 2,658reference
- Asiann = 193
- Primary endpoint
- Glucose levels during OGTT (AUCglu) for a given HbA1c level, and HbA1c for a given AUCglu, by race
Methodological detailscross-sectional analysis, observational longitudinal follow-up, multicentre (22 US clinical sites)
- Cross-sectional analysis
- Observational longitudinal follow-up
- Multicentre (22 US clinical sites)
Primary result
As reported in the abstract
HbA1c for a given AUCglu quintile, adjusted
Difference
0.15-0.20 percentage points
P < 0.05
Black · higher with Black
Difference
0.02-0.19 percentage points
P < 0.05
Asian · higher with Asian
Further findings
Diabetes diagnosed by fasting glucose (longitudinal) · 2.5 years — Black vs White · Black and Asian less likely than White
P < 0.05
| Outcome | Black | White | Asian | P value |
|---|---|---|---|---|
| Diabetes diagnosed by HbA1c (longitudinal) · 2.5 yearsBlack vs White | 28% | 10% | — not stated in the abstract | P < 0.01 |
— not stated in the abstract
Change in HbA1c over time
- Black participants with HbA1c in lower-level quintiles had greater increase in HbA1c over time vs white participants
Original publication
Racial differences in measures of glycemia in the Vitamin D and Type 2 Diabetes (D2d) Study: a secondary analysis of a randomized trial. BMJ Open Diabetes Res Care. Published 12 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →