Racial and ethnic differences in classic and 11-oxygenated androgens in men
Authors' conclusion
Circulating 11-ketotestosterone concentrations were higher in Black and Hispanic men than in White men with similar age and BMI.
Study context
- Population
- Male participants in the Dallas Heart Study-2; mean age 51 ± 10 years
- Participants
- 1,025 men
- Exposure
- Classic and 11-oxygenated androgens across races/ethnicities
- Blackn = 478
- Hispanicn = 141
- Whiten = 375reference
- Other racesn = 31
- Outcome
- Serum androstenedione, testosterone and 11-oxyandrogens by liquid chromatography-tandem mass spectrometry, compared across races
Methodological detailsmultiethnic, adjusted for age, BMI and comorbidities
- Multiethnic
- Adjusted for age, BMI and comorbidities
Main finding
As reported in the abstract
Β (testosterone)
47.06 ng/dL
P < 0.05
± 13.05; adjusted for age and BMI
Β (11-ketotestosterone)
7.30 ng/dL
P < 0.05
± 1.90; adjusted for age and BMI
Observational data: associations, not effects.
Further findings
Androgens by BMI (race- and age-adjusted)
- Testosterone and androstenedione decreased with BMI; all 11-oxyandrogens increased with BMI (P < 0.05)
Androgens by age (race- and BMI-adjusted)
- 11β-hydroxyandrostenedione increased with age (P < 0.001); all other androgens stable across ages
Original publication
Racial and ethnic differences in classic and 11-oxygenated androgens in men. J Clin Endocrinol Metab. Published 14 August 2026. doi:10.
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