Investigating a Mineralocorticoid Receptor Mediation of an Ultra‐Short Feedback Loop Regulating Aldosterone Production in Humans
Primary result · Change in aldosterone, baseline to post-cosyntropin infusionResult — go to the resultDifference 5.16 ± 2.01 ng/dLAuthors' conclusion
In humans, MR antagonist treatment led to a greater increase in aldosterone in response to cosyntropin stimulation as compared to placebo, but not after ANGII stimulation.
Study context
- Population
- Healthy participants on a low sodium diet (10 mEq/day)crossover
- Participants
- 23 participants
- Comparison
- Eplerenone vs fludrocortisone vs placebo
- Primary endpoint
- Change in aldosterone between baseline and post-cosyntropin infusion
Methodological detailsdouble-blinded, 3-way crossover, Multi-level mixed effects linear regression, Study drugs given at 6:30AM on 3 separate days, 48 h apart; after 90 min, angiotensin-II (ANGII) infusion 45 min, then 60 min later cosyntropin 45 min
- Double-blinded
- 3-way crossover
- Multi-level mixed effects linear regression
- Study drugs given at 6:30AM on 3 separate days, 48 h apart; after 90 min, ANGII infusion 45 min, then 60 min later cosyntropin 45 min
Primary result
As reported in the abstract
Change in aldosterone, baseline to post-cosyntropin infusion
Difference
5.16 ± 2.01 ng/dL
P = 0.01
Further findings
Change in aldosterone with ANGII stimulation
- No differences with either eplerenone or fludrocortisone vs placebo
Original publication
Investigating a Mineralocorticoid Receptor Mediation of an Ultra‐Short Feedback Loop Regulating Aldosterone Production in Humans. Clin Endocrinol (Oxf). Published 12 August 2026. doi:10.
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