Impact of adrenalectomy on metabolic alterations and quality of life in mild autonomous cortisol secretion: results from the randomized CHIRACIC trial
Primary result · Loss of >5% body weight (overweight/obese patients)Result — go to the resultDifference 22 % 95% CI −2% to 39%Authors' conclusion
The beneficial effects of adrenalectomy on excess weight, metabolic disorders and QoL demonstrated in the CHIRACIC trial are more limited than those observed for hypertension.
Study context
- Population
- Patients with unilateral adrenal incidentalomas and mild autonomous cortisol secretion (MACS); 93% overweight/obese, 71% prediabetic/diabetic, 90% dyslipidaemic
- Participants
- 48 patients
- Comparison
- Adrenalectomy vs conservative management
- Adrenalectomyn = 23
- Conservative managementn = 25reference
Methodological detailsmulticentre, superiority, open-label
- Multicentre
- Superiority
- Open-label
Primary result
As reported in the abstract
Loss of >5% body weight (overweight/obese patients) · 13 months
Difference
22 %
95% CI −2% to 39%
By group
Adrenalectomyvs Conservative management
difference 22 % (95% CI −2% to 39%)
Further findings
| Outcome | Adrenalectomy | Conservative management | Difference (95% CI) | |
|---|---|---|---|---|
| Glycemic status improved (dysglycemic patients) | 44% | 33% | 10% (−22% to 43%) | |
| −40−200204060Difference (linear scale) |
Dyslipidemia improved (dyslipidemic patients)
- Dyslipidemia improved in adrenalectomized dyslipidemic patients
- 20%
- Dyslipidemia improved in conservatively treated dyslipidemic patients
- 0 (none)
Quality of life (QoL)
- Changes in QoL were not different between groups
Original publication
Impact of adrenalectomy on metabolic alterations and quality of life in mild autonomous cortisol secretion: results from the randomized CHIRACIC trial. Eur J Endocrinol. Published 11 August 2026. doi:10.
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