Elevated Blood Pressure and Aldosterone Dysregulation in Young Black Women Versus White Women on Controlled Sodium Diets
Authors' conclusion
Young Black women had increased SBP and ARR as compared to White women on LIB and RES diets, which offers insights into the possible mechanisms for the increased hypertension and cardiovascular disease risk in an at-risk and understudied population.
Study context
- Population
- Hypertensive and normotensive women (ages 18–71), International Hypertensive Pathotype consortium, maintained on LIB (>200 mEq sodium/day) and restricted sodium (RES) (10 mEq sodium/day) diets
- Participants
- 525 participants
- Exposure
- Black vs White women on liberal and restricted sodium diets
- Outcome
- SBP
Methodological detailscontrolled sodium diets, multivariate regression adjusted for age, race, study site, BMI
- Controlled sodium diets
- Multivariate regression adjusted for age, race, study site, BMI
Main finding
As reported in the abstract
SBP, women aged 18-50
Difference (LIB diet)
+8.7 ± 2.7 mmHg
P = 0.002
Black women
Difference (RES diet)
+8.5 ± 2.5 mmHg
P = 0.001
Black women
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| SBP, normotensive nonobese women aged 18-35Black women vs White women · higher with Black women | difference (LIB diet) +7.9 ± 2.4 mmHg | P = 0.001 |
| SBP, normotensive nonobese women aged 18-35Black women vs White women · higher with Black women | difference (RES diet) +7.6 ± 2.7 mmHg | P = 0.005 |
ARR and aldosterone suppression-stimulation index, younger women
- Younger Black women had higher ARR on both LIB and RES diets and a higher sodium-modulated aldosterone suppression-stimulation index (aldosterone dysregulation)
Association between systolic blood pressure (SBP) and ARR, younger women
- Significant association between SBP and ARR on both LIB and RES diets in younger Black women, not in White women
Original publication
Elevated Blood Pressure and Aldosterone Dysregulation in Young Black Women Versus White Women on Controlled Sodium Diets. J Clin Endocrinol Metab. Published 31 August 2023. doi:10.
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