Subtype-specific Body Composition and Metabolic Risk in Patients With Primary Aldosteronism
Authors' conclusion
Patients with bilateral PA were more obese and had higher VFA levels than those with lateralized PA. Despite a milder form of PA, this metabolically unfavorable visceral fat distribution may lead to a higher metabolic risk in patients with bilateral PA.
Study context
- Population
- Patients with primary aldosteronism (PA) (females, n = 210) and 1:10 age- and sex-matched healthy controls; Skeletal muscle area (SMA), subcutaneous fat area and visceral fat area (VFA) at third lumbar spine by abdominal CT400 PA, 4000 controls
- Comparison
- Bilateral PA vs lateralized PA
- Healthy controlsn = 4,000
- Outcome
- VFA/BMI ratio
Methodological details1:10 age- and sex-matched healthy controls, CT-based body composition analysis
- 1:10 age- and sex-matched healthy controls
- CT-based body composition analysis
Main finding
As reported in the abstract
- VFA/body mass index (BMI) ratio, men: Bilateral PA vs Lateralized PA
- 5.77 ± 2.69 vs 4.56 ± 2.35
- VFA/BMI ratio, women: Bilateral PA vs Lateralized PA
- 4.03 ± 2.58 vs 2.53 ± 2.05
- VFA/BMI ratio significantly higher in bilateral PA than lateralized PA
- all P < .001
Observational data: associations, not effects.
Further findings
BMI
- Bilateral PA had higher BMI in both sexes
- all P < .05
HbA1c and diabetes prevalence, women
- HbA1c and prevalence of DM higher in female bilateral PA than lateralized PA
- all P < .05
SMA by autonomous cortisol secretion (ACS)
- PA with ACS showed decreased SMA vs without ACS
VFA and VFA/BMI vs healthy controls
- All bilateral PA and female lateralized PA had significantly higher VFA and VFA/BMI than healthy controls
Original publication
Subtype-specific Body Composition and Metabolic Risk in Patients With Primary Aldosteronism. J Clin Endocrinol Metab. Published 30 August 2023. doi:10.
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