Body composition and cardiometabolic risks of patients with adrenal tumours in relation to hormonal activity: a large cross-sectional single-centre study
Authors' conclusion
Adrenal tumours are associated with altered body composition. Even patients with non-functioning adenoma and MACS had increased VF area and lower muscle and fat attenuation compared with controls, indicating potential cardiometabolic risks.
Study context
- Population
- Consecutive adults with adrenal tumours, single centre; skeletal muscle and fat area and attenuation at L3 measured by CT
- Participants
- 2,971 adrenal tumour patients
- Exposure
- Adrenal tumour subtypes vs matched controls
- Non-functioning adenoman = 1,354
- Mild autonomous cortisol secretion (MACS)n = 786
- Outcome
- Body composition (area and attenuation of skeletal muscle and fat at L3 on CT)
Methodological detailsretrospective, single-centre, age-, sex- and BMI-matched controls at 1:3 ratio
- Retrospective
- Single-centre
- Age-, sex- and BMI-matched controls at 1:3 ratio
Main finding
As reported in the abstract
Body composition by adrenal hormone excess
Visceral fat (VF) area to skeletal muscle area ratio, highest: Cushing's syndrome (CS)
1.14
VF area to skeletal muscle area ratio, lowest: Pheochromocytoma (PHEO)
0.52
Observational data: associations, not effects.
Further findings
Cardiometabolic outcomes (hypertension, dyslipidaemia); prevalence ratios by Poisson regression
- MACS had higher risks of hypertension and dyslipidaemia than NFA
Original publication
Body composition and cardiometabolic risks of patients with adrenal tumours in relation to hormonal activity: a large cross-sectional single-centre study. Eur J Endocrinol. Published 27 February 2025. doi:10.
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