Pubertal increment in insulin resistance is negatively related to lumbar bone mineral density in 18-year-old males
Authors' conclusion
Pubertal increment in IR has a potential diminishing effect on lumbar spine bone mineral density accrual independently of body composition parameters. Further studies are needed to clarify whether monitoring HOMA-IR during puberty may identify subjects at increased risk of low peak bone mass and possible osteoporosis in the future.
Study context
- Population
- Boys studied annually during puberty (12 years at baseline) and at follow-up at age 18 years
- Participants
- 85 participants
- Outcome
- Lumbar spine and total body bone mineral characteristics as predicted by pubertal change in homeostatic model assessment of IR (HOMA-IR)
- Follow-up
- Age 18 years
Methodological detailslongitudinal, observational
- Longitudinal
- Observational
Main finding
As reported in the abstract
Pubertal increment in HOMA-IR as predictor of lumbar spine BMD, adjusted for baseline bone indices and body composition
Lumbar spine bone mineral areal density, β (p = 0.005)
- 0.202
Lumbar spine bone mineral apparent density, β (p = 0.005)
- 0.235
Observational data: associations, not effects.
Original publication
Pubertal increment in insulin resistance is negatively related to lumbar bone mineral density in 18-year-old males. Osteoporos Int. Published 11 November 2022. doi:10.
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