Impact of Aromatase Inhibition on Bone Mineral Density and Structure: A Randomized Controlled Trial in Boys With Delayed Puberty
Authors' conclusion
Testosterone treatment increased bone formation markers and predicted greater BMC accrual than Lz at metabolically active skeletal sites. These findings reinforce the anabolic role of androgens, partly mediated by estrogens, in early pubertal bone development. A short, 6-month treatment with Lz did not appear detrimental to bone accrual based on pQCT parameters. However, these findings do not allow conclusions regarding skeletal safety of longer Lz use.
Study context
- Population
- Boys with delayed puberty
- Participants
- 27 participants
- Comparison
- Letrozole vs low-dose testosterone
- Letrozole (Lz)n = 15
- Tn = 12
Methodological detailsprospective
- Prospective
Primary result
As reported in the abstract
T
18.1
mean · SD 25.4 · mg/mm
Lz
−1.8
mean · SD 1.0 · mg/mm
P = 0.043
Further findings
| Outcome | P value |
|---|---|
| Bone formation markers (P1NP, BAP) · 0 to 3 monthsGreater increase with T | P = 0.001-.014 |
Cortical or endosteal parameters
- No significant between-group differences
Correlation of testosterone change with bone mineral content (BMC) change at distal radius
- Positive correlation in both groups
- both P = .041
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →