Aromatase Inhibitors Treatment Alone or With GH Increases Final Height in Short-statured Pubertal Boys—Real-world Data
Authors' conclusion
AI treatment extends the growth period, resulting in an AHt surpassing initial predictions. Our findings underscore the potential of AI treatment in midpubertal boys with a short PAHt due to advanced BA and in those treated with GH for ISS.
Study context
- Population
- Midpubertal boys with predicted adult height below the third percentile due to advanced bone age or idiopathic short stature (ISS); tertiary pediatric endocrine referral center
- Exposure
- Aromatase inhibitors (AI) alone vs matched untreated controls; GH plus AI vs GH only
- AI onlyn = 27
- GH&AIn = 16
- Outcome
- Achieved adult height in AI-treated boys vs controls and the predicted adult height
Methodological detailsmatched untreated controls, tertiary pediatric endocrine referral center
- Matched untreated controls
- Tertiary pediatric endocrine referral center
Main finding
As reported in the abstract
Adult height
AI only vs Controls: P = 0.003 · GH&AI vs GH only: P = 0.194
Observational data: associations, not effects.
Further findings
| Outcome | AI only | Controls | GH&AI | GH only | P value |
|---|---|---|---|---|---|
| Difference between adult height and baseline predicted adult heightAI only vs Controls | 3.8 ± 3.5 cm | −0.3 ± 5.0 cm | 7.5 ± 5.2 cm | 4.3 ± 3.6 cm | P = 0.001 |
| Difference between adult height and baseline predicted adult heightGH&AI vs GH only | P = 0.050 | ||||
| Median duration of AI treatmentYears | 2.8 | — not stated in the abstract | 2 | — not stated in the abstract |
— not stated in the abstract
Bone age SD score and predicted adult height during treatment · throughout treatment
- Decrease in bone age (BA) SD score, AI only
- P = 0.009
- Decrease in BA SD score, GH&AI
- P = 0.029
- Improvement in predicted adult height (PAHt), AI only
- P = 0.003
- Improvement in PAHt, GH&AI
- P = 0.037
- AI-treated groups gained height similarly to controls
Original publication
Aromatase Inhibitors Treatment Alone or With GH Increases Final Height in Short-statured Pubertal Boys—Real-world Data. J Clin Endocrinol Metab. Published 7 April 2025. doi:10.
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