Determination of Androgen Bioactivity by an In Vitro Assay During Pubertal Transition in Healthy Boys
Authors' conclusion
Androgen bioactivity was undetectable before pubertal onset but measurable after in most boys, reflecting both the bioassay's lower sensitivity and potential physiological changes in androgen bioactivity during early puberty. Further studies are needed to clarify these observations.
Study context
- Population
- Healthy boys from the Copenhagen Puberty Study II (2006–2011) during pubertal transition; pubertal onset = testicular enlargement ≥ 4 mL by palpation
- Participants
- 10 participants
- Exposure
- Androgen bioactivity by in vitro androgen receptor (AR) bioassay vs total T and free T
- Outcome
- Androgen bioactivity and serum total T
Main finding
As reported in the abstract
Measurability of androgens across pubertal onset
- Androgen bioactivity unmeasurable before puberty; measurable 0.8-1.7 years after pubertal onset
- 9 of 10 boys
- Total T and free T measurable prepubertally
- all boys
- Total T and free T increased before pubertal onset
- 2 boys
- Correlation of androgen bioactivity with total T
- r = 0.93, p < 0.001
- Correlation of androgen bioactivity with free T
- r = 0.93, p < 0.001
Observational data: associations, not effects.
Further findings
ROC accuracy
Original publication
Determination of Androgen Bioactivity by an In Vitro Assay During Pubertal Transition in Healthy Boys. Clin Endocrinol (Oxf). Published 4 April 2025. doi:10.
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