Puberty‐Promoting Treatment and Psychosocial Well‐Being in Boys With Constitutional Delay of Puberty: A Randomized Controlled Trial
Authors' conclusion
Overall, boys with CDGP exhibited a generally docile temperament. The administration of puberty-promoting treatments did not result in any adverse psychosocial effects on the temperament characteristics assessed.
Study context
- Population
- Boys with constitutional delay of growth and puberty (CDGP)randomized
- Participants
- 30 participants
- Comparison
- Letrozole vs testosterone
- Lzn = 15
- Tn = 15reference
- Primary endpoint
- Temperament characteristics emotionality, activity and sociability (emotionality, activity, and sociability (EAS)), standardized validated questionnaire
- Follow-up
- 0, 6 and 12 months
Methodological detailsopen-label
- Open-label
Primary result
Sociability · after 6-month treatment
Difference
−0.48
95% CI 0.89 to −0.08
P = 0.019
As reported in the abstract
Further findings
| Outcome | Difference (95% CI) | P value | |
|---|---|---|---|
| Sociability · 12-month follow-upTvs LzSociability higher with Lz | −0.72 (−1.12 to −0.32) | P = 0.001 | |
| −1.5−1−0.500.5Difference (linear scale) |
Temperament of boys with CDGP vs local peers
- More withdrawn
- P = 0.02
- Less anger
- P = 0.02
- Less fear
- P = 0.02
Emotionality of boys with CDGP vs local and national controls
- CDGP boys less negatively emotional than peers
- P = 0.04
Original publication
Puberty‐Promoting Treatment and Psychosocial Well‐Being in Boys With Constitutional Delay of Puberty: A Randomized Controlled Trial. Clin Endocrinol (Oxf). Published 6 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →