Pediatric endocrinology

Psychosocial Stress Trajectories Are Associated With Puberty Timing: Findings From a 7-Year Cohort in Chongqing, China

J Clin Endocrinol MetabPublished Prospective cohort study

Authors' conclusion

Chronic PS may be associated with delayed onset of several pubertal signs in both girls and boys. It may also accelerate testicular development of boys, indicating its varying impact on pubertal timing during early and later stages.

Study context

Population
Girls and boys in a Chinese cohort, Chongqing (2015–2022); pubertal outcomes examined every 6 months, stressful life events assessed 7 times732 girls and 688 boys
Exposure
PS trajectories vs "low, gradual decline" trajectory
Outcome
Puberty timing (pubertal outcomes)
Methodological details7-year cohort, repeated measurements, group-based trajectory model, Cox model adjusted for age, BMI and socioeconomic factors
  • 7-year cohort
  • Repeated measurements
  • Group-based trajectory model
  • Cox model adjusted for age, BMI and socioeconomic factors

Main finding

As reported in the abstract

Pubertal outcomes by PS trajectory
Each group vs low, gradual declineHazard ratio (95% CI)
Moderate, gradual declinetotal PS; menarche in girls (late)
0.816(0.677–0.983)
Moderate, gradual declinetotal PS; pubic hair in girls (late)
0.729(0.609–0.872)
Moderate, gradual declinetotal PS; axillary hair in girls (late)
0.803(0.661–0.975)
High, rise then declinePS from family life; axillary hair in girls (delayed)
0.752(0.571–0.990)
High, rise then declinePS from academic adaptation; axillary hair in boys (late)
0.670(0.476–0.945)
High, rise then declinePS from life adaptation; axillary hair in boys (late)
0.642(0.445–0.925)
Moderate, gradual declinePS from peer relationships; testicular development in boys (early)
1.353(1.108–1.653)

Observational data: associations, not effects.

Original publication

Psychosocial Stress Trajectories Are Associated With Puberty Timing: Findings From a 7-Year Cohort in Chongqing, China. J Clin Endocrinol Metab. Published 6 June 2024. doi:10.1210/clinem/dgae378

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