Approaches to Identify Factors Associated with Pubertal Timing in Self-Limited Delayed Puberty
Authors' conclusion
By illustrating the heterogeneity within self-limited DP and identifying factors underlying this heterogeneity, our study suggests that there may be multiple causes of self-limited DP. However, our ability to determine when puberty will eventually occur remains limited. Dissecting self-limited DP into its component subtypes may inform future studies of the mechanisms contributing to pubertal delay as well as studies of the short- and long-term outcomes of self-limited DP.
Study context
- Population
- Girls and boys with self-limited delayed puberty (constitutional delay) at an academic medical center, 2000–201599 girls · 228 boys
- Outcome
- Factors associated with pubertal timing
Methodological detailssingle academic medical center, group-based trajectory modeling, latent-variable factor analysis, time-to-event analyses
- Single academic medical center
- Group-based trajectory modeling
- Latent-variable factor analysis
- Time-to-event analyses
Main finding
As reported in the abstract
Associations with pubertal timing
- Correlation of pubertal timing with bone age
- p = 0.01
- Correlation of pubertal timing with childhood height
- p = 0.004
- Correlation of pubertal timing with midparental target height
- p < 0.001
Observational data: associations, not effects.
Further findings
Growth trajectories
- Two distinct growth trajectories: stable and declining height percentiles
Latent-variable factor analysis of clinical characteristics
- Five factors: genetic height potential, BMI, childhood growth, parental pubertal delay, medical issues (ADHD and inhaled glucocorticoid use)
Original publication
Approaches to Identify Factors Associated with Pubertal Timing in Self-Limited Delayed Puberty. Horm Res Paediatr. Published 25 August 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →