Bone microstructural and strength changes over 1 year in children with osteogenesis imperfecta are comparable to age- and sex-matched healthy controls
Authors' conclusion
In summary, baseline trabecular bone density, trabecular and cortical microstructure, and strength were lower in metaphyseal regions of children with OI. At diaphysis, children with OI had lower bone area and strength. While longitudinal changes over 1 yr were generally comparable, certain outcomes demonstrated differences. These data are essential for powering future clinical trials.
Study context
- Population
- Children with osteogenesis imperfecta under bisphosphonate treatment and age- and sex-matched controls
- Participants
- 20 vs 20
- Exposure
- Children with osteogenesis imperfecta (OI) on bisphosphonate treatment vs age- and sex-matched healthy controls
- OIn = 20
- Controlsn = 20reference
- Outcome
- Changes in bone density, microstructure and strength at the metaphysis and diaphysis of the radius and tibia, and LS bone mass and area
- Follow-up
- 1 yr
Methodological detailsage- and sex-matched controls, HR-pQCT, DXA, An algorithm was developed to correct stack misalignment of double-stack metaphyseal scans
- Age- and sex-matched controls
- HR-pQCT
- DXA
- An algorithm was developed to correct stack misalignment of double-stack metaphyseal scans
Main finding
As reported in the abstract
1-yr changes in bone density, microstructure and strength
- At the tibial and radial metaphysis, 1-yr increases in most measurements were similar for both groups
- Cortical volumetric BMD (vBMD) and trabecular separation (radius) only increased in the OI group
- Trabecular vBMD, volume fraction (tibia), number (tibia) and total vBMD (radius) only increased in the control group
- At the tibia and radius diaphysis, cortical vBMD increased in the OI group
- Tibial Ct.Po decreased in children with OI
- Lumbar spine (LS): similar longitudinal changes
Observational data: associations, not effects.
Further findings
Baseline bone parameters
- Tibial metaphysis: lower total and trabecular vBMD, trabecular and cortical microstructure, and strength in OI
- Radial metaphysis: lower trabecular microstructure and strength in OI
- Tibial and radial diaphysis: lower bone area and strength in OI
- LS: lower bone mass, density and area in OI
Original publication
Bone microstructural and strength changes over 1 year in children with osteogenesis imperfecta are comparable to age- and sex-matched healthy controls. J Bone Miner Res. Published 4 October 2025. doi:10.
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