Bone microarchitecture and strength assessment in adults with osteogenesis imperfecta using high-resolution peripheral quantitative computed tomography (HR-pQCT): normative comparison and challenges
Authors' conclusion
To conclude, especially trabecular bone microarchitecture and bone strength were impaired in adults with OI.
Study context
- Population
- Adults (men and women) with Sillence osteogenesis imperfecta (OI) type I, III, or IV102 radius, 105 tibia scans usable
- Participants
- 118 adults
- Outcome
- Bone microarchitecture and strength (HR-pQCT Z-scores vs normative data) at distal radius and tibia
Methodological detailssecond-generation HR-pQCT, extremity-length-dependent scan protocol, comparison with normative HR-pQCT data
- Second-generation HR-pQCT
- Extremity-length-dependent scan protocol
- Comparison with normative HR-pQCT data
Main finding
As reported in the abstract
HR-pQCT Z-scores vs normative data (scans without deviated axial angle)
- Radius trabecular bone mineral density (BMD) Z-score (mean ± SD)
- −1.6 ± 1.3
- Radius trabecular number Z-score (mean ± SD)
- −2.5 ± 1.4
- Radius trabecular separation Z-score
- −2.7 (IQR: 2.7)
- Radius stiffness Z-score
- −1.4 ± 1.5
- Radius failure load Z-score
- −1.1 ± 1.2
Observational data: associations, not effects.
Further findings
- Radius scans with deviated axial angle
- 11 (11%)
- Tibia scans with deviated axial angle
- 14 (13%)
- In deviated scans, proportion of Z-scores <−4 or >4 significantly higher for trabecular BMD and separation (radius) or most total and trabecular parameters (tibia)
- Compared with axial angle data of 13 young women
Original publication
Bone microarchitecture and strength assessment in adults with osteogenesis imperfecta using HR-pQCT: normative comparison and challenges. J Bone Miner Res. Published 25 January 2024. doi:10.
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