Damaged bone microarchitecture by Trabecular Bone Score (TBS) and low appendicular muscle mass: main risk factors for vertebral and non-vertebral fractures in women with long-standing rheumatoid arthritis
Authors' conclusion
In women with long-term RA, markers of fractures differed between distinct skeletal sites (vertebral and non-vertebral). The magnitude of association of bone/muscle parameters with fracture (TBS for VF and appendicular muscle mass for NVF) was greater than that of the association between RA activity and fracture.
Study context
- Population
- Women with established rheumatoid arthritis (RA) (ACR 2010); median age 55 [22–86] years; mean disease duration 16.2 years265 analysed
- Participants
- 300 women
- Outcome
- Risk factors for vertebral (VF) and non-vertebral fractures (NVF), including clinical, laboratory and DXA parameters (BMD, TBS, muscle mass)
Methodological detailsmultivariate logistic regression
- Multivariate logistic regression
Main finding
As reported in the abstract
- Prevalence of VF
- 30.6%
- Prevalence of non-vertebral fractures (NVF)
- 17.4%
- VF: TBS, OR 1.6 (95% CI 1.09-2.36)
- p = 0.017
- VF: C-reactive protein (CRP), OR 1.54 (95% CI 1.15-2.08)
- p = 0.004
- VF: parathormone, OR 1.24 (95% CI 1.05-1.45)
- p = 0.009
- NVF: Body mass index (BMI), OR 0.90 (95% CI 0.82-0.99)
- p = 0.025
- NVF: hip bone mineral density (BMD), OR 1.82 (95% CI 1.10-3.03)
- p = 0.02
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Damaged bone microarchitecture by Trabecular Bone Score (TBS) and low appendicular muscle mass: main risk factors for vertebral and non-vertebral fractures in women with long-standing rheumatoid arthritis. Osteoporos Int. Published 25 January 2024. doi:10.
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