Sedentary behavior does not predict low BMD nor fracture—population-based Canadian Multicentre Osteoporosis Study
Authors' conclusion
In conclusion, habitual adult SB was not associated with subsequent loss of BMD nor increased risk of fracture.
Study context
- Population
- 5708 women and 2564 men aged 25 to 80+ yr, Canadian Multicentre Osteoporosis Study; baseline (1995–7) and 10-yr self-reported sedentary behavior (SB)4,624 with fracture data
- Exposure
- SB quartiles; third/fourth vs first quartile
- Outcome
- Associations of SB with areal BMD (by DXA; FN, TH, L1-L4) and incident low trauma (fragility) osteoporotic fractures
- Follow-up
- 10 yr
Methodological detailsnationwide, 9-center, longitudinal, stratified by sex, >80% of fractures objectively confirmed by medical records or radiology reports
- Nationwide
- 9-center
- Longitudinal
- Stratified by sex
- >80% of fractures objectively confirmed by medical records or radiology reports
Main finding
As reported in the abstract
Baseline BMD by SB quartile (adjusted)
- Women in SB Q3/Q4 had lower adjusted femoral neck (FN) BMD vs Q1
- Women in SB Q3 had lower adjusted total hip (TH) BMD
- Men in SB Q3 had lower adjusted FN BMD vs Q1
- Neither baseline nor stable 10-yr SB was related to BMD change
- Neither baseline nor stable 10-yr SB was related to incident fragility fractures
- Adjusted for age, height, BMI, physical activity, sex-specific covariates
Observational data: associations, not effects.
Original publication
Sedentary behavior does not predict low BMD nor fracture—population-based Canadian Multicentre Osteoporosis Study. J Bone Miner Res. Published 24 January 2024. doi:10.
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