Characterization and Predictors of Fractures Following Hematopoietic Stem Cell Transplantation
Authors' conclusion
Regular screening to monitor bone loss should be initiated early, and counseling about the importance of general preventive measures for bone loss is warranted in HSCT recipients with a prior fracture and mean daily dose of steroids more than 0.50 mg.
Study context
- Population
- Patients older than 18 years who received hematopoietic stem cell transplantation (HSCT) from January 1, 2003 to September 30, 2015, Taiwan
- Participants
- 3,327 participants
- Outcome
- Incidence of fractures after HSCT (identified by ICD codes)
Methodological detailspopulation-based, Taiwan National Health Insurance Research Database, multivariable Cox regression
- Population-based
- Taiwan National Health Insurance Research Database
- Multivariable Cox regression
Main finding
As reported in the abstract
Fractures after HSCT
Patients with a fracture after HSCT
126
3.8%
Cumulative incidence of fractures at 5 years
5.3%
Cumulative incidence of fractures at 10 years
10.8%
Observational data: associations, not effects.
Further findings
Risk factors for fractures post HSCT (multivariable analysis)
- Fracture in the 3 years before transplant, HR
- 3.79 (2.39-6.03) (95% CI)
- Daily prednisolone dose equivalent >0.50-3.75 mg, fold increase in risk
- 1.70 (1.07-2.71) (95% CI)
- Daily prednisolone dose equivalent >3.75-15.23 mg, fold increase in risk
- 2.23 (1.32-3.76) (95% CI)
- Daily prednisolone dose equivalent >15.23 mg, fold increase in risk
- 2.93 (1.43-6.01) (95% CI)
Original publication
Characterization and Predictors of Fractures Following Hematopoietic Stem Cell Transplantation. J Clin Endocrinol Metab. Published 23 January 2024. doi:10.
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