Trabecular bone score norms in Asian‐Indians and associations with serum 25(OH)D and parathyroid hormone
Authors' conclusion
This study provides norms for TBS in Asian-Indians with gender-specific differences. Increasing age and higher BMI were associated with lower TBS. Associations of TBS with circulating PTH and/or 25(OH)D need confirmation in further studies.
Study context
- Population
- Healthy Asian-Indians aged 20–60 years; DXA-assessed trabecular-bone-score (TBS), bone-mineral-density (BMD) and vertebral fracturesnorms in 744
- Participants
- 923 participants
- Exposure
- Asian-Indian TBS norms vs existing norms
- Outcome
- Population-specific TBS norms and associations with serum 25(OH)D and intact-parathyroid hormone (iPTH)
Main finding
As reported in the abstract
TBS norm cut-offs
- 'Normal' TBS cut-off
- >1.305
- 'Partially-degraded' TBS cut-off
- 1.204-1.305
- 'Degraded' TBS cut-off
- <1.204
- Mean TBS lower in females than males
- p < .001
Observational data: associations, not effects.
Further findings
TBS to detect osteoporosis · higher with Asian-Indian norms
P < 0.001
Specificity Asian-Indian norms 97.8 · Existing norms 77.9%
Diagnostic accuracy
| Outcome | P value |
|---|---|
| TBS to detect osteoporosisHigher with Asian-Indian norms | P < 0.001 |
Congruency in TBS categories between Asian-Indian and existing norms
- Congruency
- 75%
Sensitivity of 'partially-degraded' TBS to diagnose osteopenia
- Higher with Asian-Indian norms
Factors associated with TBS (multivariable regression)
- Gender, body-mass-index (BMI), BMD-L1-L4, serum PTH, daily dietary calorie intake and calcium intake associated with TBS
- 25(OH)D inversely correlated with PTH but not associated with TBS
Original publication
Trabecular bone score norms in Asian‐Indians and associations with serum 25(OH)D and parathyroid hormone. Clin Endocrinol (Oxf). Published 7 August 2024. doi:10.
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