Bone density and trabecular bone score to predict fractures in adults aged 20–39 years: a registry-based study
Authors' conclusion
In young adults, low BMD, but not low TBS, was predictive of MOF and any fracture.
Study context
- Population
- Women and men aged 20–39 years referred for DXA testing, Manitoba Bone Density Registry77% female, mean age 32 years
- Participants
- 2,799 women
- Exposure
- Fracture risk by WHO bone mineral density (BMD) T-score category and trabecular bone score (TBS) tertile, and per SD decrement in BMD and TBS
- Outcome
- Incident major osteoporotic fracture (MOF) and any fracture
Methodological detailsCox regression, covariate-adjusted (including sex)
- Cox regression
- Covariate-adjusted (including sex)
Main finding
As reported in the abstract
Incident MOF / any fracture
Adjusted hazard ratio (major osteoporotic fracture (MOF)/any fracture)
1.20/1.45
Osteopenia
Adjusted hazard ratio (MOF/any fracture)
4.60/5.16
Osteoporosis
- Each SD decrement in BMD: MOF aHR
- 1.64
- Each SD decrement in BMD: any fracture aHR
- 1.71
Observational data: associations, not effects.
Further findings
Baseline BMD and TBS
- Mean (SD) minimum T-score
- - 0.9 (1.1)
- Mean (SD) TBS
- 1.355 (0.114)
- Osteoporosis
- 7%
- Lowest TBS tertile
- 13%
Original publication
Bone density and trabecular bone score to predict fractures in adults aged 20–39 years: a registry-based study. Osteoporos Int. Published 31 March 2023. doi:10.
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