One Year Cholecalciferol and Calcium Supplementation Improve Bone Mineral Density (BMD) But Not Trabecular Bone Score in Asymptomatic Hypovitaminosis D
Authors' conclusion
One year of cholecalciferol and calcium supplementation in asymptomatic individuals resulted in a significant rise in serum 25(OH)D, which was associated with increased BMD but not TBS.
Study context
- Population
- Healthy asymptomatic individuals with serum 25(OH)D < 50 nmol/L and low trabecular bone score (TBS) (< 1.310), from an earlier TBS norms study in Asian Indians; age 45 ± 9 years, BMI 26.7 ± 3.9 kg/m², M:F = 29:21
- Participants
- 50 individuals
- Exposure
- Cholecalciferol and calcium supplementation, before vs after
- Cholecalciferol + calciumn = 50
- Outcome
- Changes in BMD and TBS
- Follow-up
- 1 year
Methodological detailssingle-group, tertiary-care centre
- Single-group
- Tertiary-care centre
Main finding
As reported in the abstract
6 and 12 months
- BMD improved significantly from baseline at lumbar spine, total hip and femoral neck at 6 and 12 months
- p < 0.01 for all
Observational data: associations, not effects.
Further findings
Mean serum 25(OH)D (nmol/L) · baseline, 6 and 12 months
- Baseline
- 29.1 ± 11.7
- 6 months
- 68.8 ± 47.4
- 12 months
- 63.2 ± 22.2
- Significant rise
Serum intact PTH, osteocalcin and alkaline phosphatase · within 6 months
- Significant decrease in PTH, osteocalcin and alkaline phosphatase
Original publication
One Year Cholecalciferol and Calcium Supplementation Improve BMD But Not Trabecular Bone Score in Asymptomatic Hypovitaminosis D. Clin Endocrinol (Oxf). Published 30 January 2026. doi:10.
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