Hypocalcemia following denosumab in osteoporosis: Incidence and risk factors in a Saudi cohort
Authors' conclusion
Hypocalcemia following denosumab is common in real-world practice, particularly in patients on diuretics or with low vitamin D levels.
Study context
- Population
- Saudi adults with osteoporosis who received denosumab, tertiary care hospital
- Participants
- 303 adults
- Outcome
- Incidence of hypocalcaemia after denosumab
Methodological detailssingle-centre (tertiary care hospital), multivariate logistic regression
- Single-centre (tertiary care hospital)
- Multivariate logistic regression
Main finding
As reported in the abstract
Hypocalcaemia after denosumab
Hypocalcaemia incidence
21.1%
Mild (grade 1) among hypocalcaemia cases
71.9%
Asymptomatic among cases
73.4%
Observational data: associations, not effects.
Further findings
Predictors of hypocalcaemia
- Diuretic use, aOR
- 3.44 (p = 0.008)
- Vitamin D deficiency strongly associated with severe (grade 3) hypocalcaemia
Original publication
Hypocalcemia following denosumab in osteoporosis: Incidence and risk factors in a Saudi cohort. Osteoporos Int. Published 30 January 2026. doi:10.
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