The effect of pregnancy vitamin D supplementation on offspring bone mineral density in childhood: a systematic review and meta-analysis
Pooled result · Offspring whole-body-less-head BMDResult — go to the resultSMD 0.16 SD 95% CI 0.05–0.27Authors' conclusion
There are few RCTs published to address this question, and these are inconsistent in methodology and findings. However, meta-analysis of three trials suggests moderate- to high-dose vitamin D supplementation in pregnancy might increase offspring BMD in early childhood, but further trials are required to confirm this finding.
Study context
- Population
- Pregnant women in RCTs of antenatal vitamin D supplementation with offspring bone mineral density (BMD) or BMC assessed by DXA; MEDLINE and EMBASE to 13th July 2022
- Participants
- 3,250 women5 RCTs
- Comparison
- Antenatal vitamin D supplementation vs control
- Outcome
- Offspring whole-body-less-head BMD
- Follow-up
- Age 4-6 years
Methodological detailsrandom-effects meta-analysis, Cochrane Risk of Bias 2 tool, Risk of bias low in 2 studies and "of concern" in 3
- Random-effects meta-analysis
- Cochrane Risk of Bias 2 tool
- Risk of bias low in 2 studies and "of concern" in 3
Pooled result
As reported in the abstract
SMD
0.16 SD
95% CI 0.05–0.27
Vitamin Dvs Control
SMD 0.16 SD (95% CI 0.05–0.27)
Further pooled results
| Outcome | SMD (SD) (95% CI) | |
|---|---|---|
| Offspring BMC · age 4-6 yearsn = 1351 | 0.07 (- 0.04, 0.19) | |
| −0.100.10.2Difference, SD (linear scale) |
Neonatal BMD · neonatal period
- No difference between groups (2 trials, total n = 690); not meta-analysed as one trial represented 96.4%
Maternal 25-hydroxyvitamin D status
- Increased with the intervention vs control in all studies
Original publication
The effect of pregnancy vitamin D supplementation on offspring bone mineral density in childhood: a systematic review and meta-analysis. Osteoporos Int. Published 27 April 2023. doi:10.
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