Pregnancy vitamin D supplementation and bone mineral density of the mother: a post hoc analysis of the MAVIDOS randomised placebo-controlled trial
Authors' conclusion
Despite previously demonstrated benefits for the offspring skeleton in this trial, maternal BMD did not differ in the short or medium term in women randomised to 1000 IU/day vitamin D or placebo.
Study context
- Population
- Pregnant women in the MAVIDOS trial with DXA of whole body, lumbar spine and left hip after delivery
- Comparison
- Cholecalciferol 1000 IU/day in pregnancy vs placebo
- Primary endpoint
- Maternal BMD (whole body, lumbar spine (LS), left hip) by DXA
- Follow-up
- Within 2 weeks after delivery and 4 years after delivery
Methodological detailsplacebo-controlled, post hoc follow-up
- Placebo-controlled
- Post hoc follow-up
Primary result
As reported in the abstract
Maternal BMD at all sites · within 2 weeks and mean 4.1 years after delivery
- Bone mineral density (BMD) at all sites similar between randomisation groups at both time points
- Cholecalciferol vs Placebo: P > 0.05 for all
- 401 with DXA within 2 weeks; 443 at mean 4.1 years
Further findings
Change in BMD from within 2 weeks to 4 years after delivery
- BMD increased between 1 and 6% depending on site; similar between randomisation groups
- No effect of pregnancy cholecalciferol on BMD at 4 years in repeated measures modelling
- 263 with DXA at both time points
Serum 25-hydroxyvitamin D in late pregnancy
- Increased with cholecalciferol vs placebo
Original publication
Pregnancy vitamin D supplementation and bone mineral density of the mother: a post hoc analysis of the MAVIDOS randomised placebo-controlled trial. Osteoporos Int. Published 23 June 2025. doi:10.
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