Non-invasive quantification of bone (re)modeling dynamics in adults with osteogenesis imperfecta treated with setrusumab using timelapse high-resolution peripheral-quantitative computed tomography
Authors' conclusion
This study identifies a timelapse method that minimizes measurement error, which can be used in future studies to improve the uniformity of results. This non-invasive imaging biomarker revealed dose dependent bone (re)modeling outcomes from 1 year of setrusumab treatment in adults with OI.
Study context
- Population
- Adults with osteogenesis imperfecta (OI) in the ASTEROID trial
- Participants
- 78 adults29 same-day repeat scans
- Comparison
- Timelapse HR-pQCT methods; setrusumab vs zoledronic acid
- Primary endpoint
- Measurement error of timelapse HR-pQCT methods for quantifying bone formation and resorption
Methodological detailsmulticenter, same-day repeated scans, longitudinal
- Multicenter
- Same-day repeated scans
- Longitudinal
Primary result
As reported in the abstract
Timelapse measurement error
Binary input images, any registration method: error, first- and second-generation scanners respectively
≈13% and ≈8%
Density threshold 200 mgHA/cm³ with Gaussian noise reduction, both scanner generations: error
<1%
Further findings
Bone formation and resorption on longitudinal scans · baseline, 6, 12, 18, and 24 mo
- Setrusumab: dose-dependent increase in bone formation and resorption
- Zoledronic acid altered bone changes in favor of formation; no changes statistically significant
Original publication
Non-invasive quantification of bone (re)modeling dynamics in adults with osteogenesis imperfecta treated with setrusumab using timelapse high-resolution peripheral-quantitative computed tomography. J Bone Miner Res. Published 24 January 2025. doi:10.
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