Association of covert brain infarcts and white matter hyperintensities with risk of hip fracture in older adults: the Cardiovascular Health Study
Authors' conclusion
Older, community-dwelling adults with covert infarcts or WMHs may be at increased risk of hip fracture.
Study context
- Population
- Community-dwelling adults aged ≥ 65 years enrolled in the Cardiovascular Health Study with a brain MRI (1992–1993)465 incident hip fractures
- Participants
- 3,373 adults
- Exposure
- Covert brain infarcts and WMH grades on brain MRI vs no infarcts / WMH grades 0-1
- Outcome
- Incident hip fracture
- Follow-up
- Mean 12.8 years
Methodological detailscommunity-dwelling, Cox regression (hazard ratios), demographic-, medication/medical history- and fully adjusted models
- Community-dwelling
- Cox regression (hazard ratios)
- Demographic-, medication/medical history- and fully adjusted models
Main finding
As reported in the abstract
Incident hip fracture, demographic-adjusted
Hazard ratio (95% CI)
≥ 1 covert infarctvs No infarcts32% higher hazard
1.32(1.08–1.62)
WMH grades 2-3vs WMH grades 0-1
1.34(1.09–1.66)
WMH grades 4-9vs WMH grades 0-1
1.83(1.37–2.46)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident hip fracture per increase in infarct number, fully adjusted | 1.10 (0.98–1.23) | |
| 0.512Hazard ratio (log scale) |
Incident hip fracture by largest infarct size
- Risk with largest infarct ≥ 20 mm vs 3 to < 20 mm was similar
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of covert brain infarcts and white matter hyperintensities with risk of hip fracture in older adults: the Cardiovascular Health Study. Osteoporos Int. Published 10 November 2022. doi:10.
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