Sex-specific associations of vitamin D and bone biomarkers with bone density and physical function during recovery from hip fracture: the Baltimore Hip Studies
Authors' conclusion
These findings underscore the importance of vitamin D assessment in older men and missed opportunities in both sexes for vitamin D supplementation and pharmaceutical treatment to reduce bone resorption after hip fracture.
Study context
- Population
- Community-dwelling, ambulatory adults aged 65 years and over with hip fracture, Baltimore Hip Studies 7th cohort
- Participants
- 157 vs 154
- Exposure
- Men vs women
- Menn = 157
- Womenn = 154reference
- Outcome
- Sex differences in 25OHD and bone turnover markers, and associations with BMD and physical function, during the year after hip fracture
- Follow-up
- 12 months
Main finding
As reported in the abstract
25OHD on admission for hip fracture
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| PINP · 6 monthsPINP higher in men | P = 0.04 |
β-CTX-I · admission, 2 and 6 months
- Higher in men on admission, and at 2 and 6 months (all p < 0.05)
PTH
- No significant differences between men and women
Associations with bone mineral density (BMD)
- Higher 25OHD and PINP in women only, and lower β-CTX-I and PTH in both sexes, associated with greater BMD
Associations with short physical performance battery (SPPB)
- Higher 25OHD associated with higher SPPB scores in both sexes
Original publication
Sex-specific associations of vitamin D and bone biomarkers with bone density and physical function during recovery from hip fracture: the Baltimore Hip Studies. Osteoporos Int. Published 20 March 2025. doi:10.
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