Prevalence and incidence of osteoporotic vertebral fractures in community-dwelling European older adults: an observational analysis of the DO-HEALTH trial
Authors' conclusion
This study suggests a high prevalence and incidence of VFs in community-dwelling European older adults. Underdiagnosis may be even more prevalent than previously observed, and treatment rates were low.
Study context
- Population
- Community-dwelling European adults aged ≥70 years in the DO-HEALTH trial, subsample from four sites with DXA (mean age 74.9 years, 63.1% women, 77.0% osteopenia or osteoporosis (OP))
- Participants
- 1,488 adults
- Primary endpoint
- Prevalence and incidence of osteoporotic VFs and VF progressions
- Follow-up
- three-year follow-up
Methodological detailsobservational analysis, multicentre (four study sites equipped with DXA machines)
- Observational analysis
- Multicentre (four study sites equipped with DXA machines)
Primary result
As reported in the abstract
Prevalence: ≥1 radiographic vertebral fracture (VF) at baseline
144
9.7%
Incidence over 3-year follow-up: 50 participants sustained 58 new radiographic VFs, incidence rates (IR)
1.4 (1.1, 1.9) (95% CI)
VF progressions: 31 participants sustained 35 progressions (N = 157), IR
7.7 (5.5, 10.7) (95% CI)
Further findings
Clinically recognized new radiographic VFs · three-year follow-up
- Clinically recognized, of 58 radiographic VFs
- 12 (20.7%)
OP medication use among participants with VF at baseline
- Reported OP medication use
- 19.4%
Prevalence and incidence by sex, age and bone status
- Significantly higher in women, older participants and those with osteopenia or OP vs normal bone density
Original publication
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