Obesity Variants in the GIPR Gene Are not Associated With Risk of Fracture or Bone Mineral Density
Authors' conclusion
Missense variants in GIPR, or burden of LoF variants in the gene, are not associated with risk of fractures or with lower BMD.
Study context
- Population
- General population (fracture sites: any, hip, vertebral, forearm) and postmenopausal women (nonvertebral and osteoporotic fractures)up to
- Participants
- 1.2 million participants
- Comparison
- GIPR missense variants and burden of predicted loss-of-function (LoF) variants vs non-carriers
- Outcome
- Risk of fracture and BMD (DXA lumbar spine, femoral neck, total body; heel US-estimated BMD)
Pooled result
As reported in the abstract
- None of the 3 GIPR missense variants significantly associated with increased fracture risk or lower bone mineral density (BMD)
- LoF burden in GIPR not associated with fractures or DXA-measured BMD, but associated with eBMD
Original publication
Obesity Variants in the GIPR Gene Are not Associated With Risk of Fracture or Bone Mineral Density. J Clin Endocrinol Metab. Published 20 December 2023. doi:10.
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