Prevalence and Pathogenesis of Macro-Thyrotropin in Neonates: Analysis of Umbilical Cord Blood from 939 Neonates and Their Mothers
Authors' conclusion
Macro-TSH was found in 0.43% of neonates, and their mothers all had macro-TSH as well.
Study context
- Population
- Neonates and their mothers; umbilical cord blood samplesneonates and their mothers
- Participants
- 939 umbilical cord blood samples
- Outcome
- Prevalence and nature of macro-TSH in neonates
Main finding
As reported in the abstract
Macro-TSH prevalence in neonates (125I-TSH binding study)
Neonates with significantly high 125I-TSH binding ratios (macro-TSH)
4
0.43%
Observational data: associations, not effects.
Further findings
Polyethylene glycol (PEG) screening
- Samples with PEG precipitation ratio of TSH >68.9% (mean + SD)
- 138
- Human anti-mouse antibodies among these
- 9
- Remaining samples examined by 125I-TSH binding study and gel filtration chromatography (GFC)
- 129
Autoantibody characterization (one baby and its mother)
- Low affinity and high specificity to human TSH; nature very similar between baby and mother
GFC
- Macro-TSH revealed by GFC in only one baby and its mother
Original publication
Prevalence and Pathogenesis of Macro-Thyrotropin in Neonates: Analysis of Umbilical Cord Blood from 939 Neonates and Their Mothers. Thyroid. Published 20 December 2022. doi:10.
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