Divergent metabolic phenotypes in two genetic syndromes of low insulin secretion
Authors' conclusion
A distinct metabolic phenotype depending on GH counter-regulatory status, associates with diabetes development and excess glucose-induced IAPP secretion.
Study context
- Population
- Adults with life-long diminished insulin secretion (DIS): Laron syndrome (LS) and Guevara-Rosenbloom syndrome (GRS), and controls
- Exposure
- LS vs GRS vs controls
- Outcome
- Metabolic phenotype (body composition, adipokines, IGF axis, 5-hour OGTT)
Main finding
As reported in the abstract
- Both syndromic cohorts displayed DIS during oral glucose tolerance test (OGTT)
- LS: higher total and high molecular weight (HMW) adiponectin, lower IGF-I, IGF-II and IGF-Binding Protein-3 than other groups
- LS: normal glycemic responses during OGTT with the lowest IAPP secretion
- GRS: higher protein glycation, deficient glucose control during OGTT, increased IAPP secretion
Observational data: associations, not effects.
Original publication
Divergent metabolic phenotypes in two genetic syndromes of low insulin secretion. Diabetes Res Clin Pract. Published 19 December 2022. doi:10.
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