Role of the GH-IGF Axis in Statural Growth and Harmonious Body Proportionality: In Search of Vitruvian Man?
Authors' conclusion
These findings indicate that individuals homozygous for the GHR mutation have disharmonious body proportions due to abnormal GH/IGF-I action on the growth of the long bones. Contrary to common assumptions, disruption of the GH-IGF axis results in disproportionality and disharmonious growth.
Study context
- Population
- Ecuadorian cohort of adults with GH insensitivity, their relatives and unrelated controls
- Participants
- 201 adults
- Exposure
- Adults with GH insensitivity (GHI) due to homozygous GHR mutation vs carrier and noncarrier relatives and noncarrier unrelated controls
- Outcome
- Anthropometric measurements and body proportions
Methodological detailsepidemiological, noninterventional
- Epidemiological
- Noninterventional
Main finding
As reported in the abstract
- Sex-specific distributions of height, lower segment, upper segment, arm span, head circumference (HC), and hand and foot length lower in GHI than other groups
- GHI had lowest lower segment/height (Ht), highest upper segment/Ht, lowest arm span/Ht and highest HC/Ht ratio
- Hand and foot length/Ht ratios not uniformly affected
Observational data: associations, not effects.
Further findings
- Serum IGF-I positively logarithmically correlated with all body measurements but negatively correlated with HC/Ht ratio
Original publication
Role of the GH-IGF Axis in Statural Growth and Harmonious Body Proportionality: In Search of Vitruvian Man? J Clin Endocrinol Metab. Published 28 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →