Delayed Thyrotropin Rise in Preterm Newborns: Value of Multiple Screening Samples and of a Detailed Clinical Characterization
Authors' conclusion
Permanent CH appears to be rarer than transient CH among preterm newborns (1/1789 vs. 1/596).
Study context
- Population
- Preterm newborns (<37 weeks of gestation) screened at the Newborn Screening Center of Université Libre de Bruxelles, January 2014–December 2023
- Participants
- 3,578 newborns
- Outcome
- Incidence of transient and permanent CH and delayed TSH rise in preterm newborns
Methodological detailssingle-centre, with literature review, Literature review performed to identify cases of permanent congenital hypothyroidism (CH) with delayed TSH rise in preterm cohorts
- Single-centre
- With literature review
- Literature review performed to identify cases of permanent CH with delayed TSH rise in preterm cohorts
Main finding
As reported in the abstract
Incidence of CH in preterm newborns
- Diagnosed with CH
- 10 (0.3%)
- Transient CH
- 6 out of 10
- Permanent CH
- 2; 1 in 1789 (0.05%)
- Detected at first dry blood spot (DBS)
- 6
- Detected at subsequent DBS
- 4
- Permanent CH with delayed TSH rise
- 1 of 2
Observational data: associations, not effects.
Further findings
- Genetic testing helped establish diagnosis of permanent CH with gland in situ
Original publication
Delayed Thyrotropin Rise in Preterm Newborns: Value of Multiple Screening Samples and of a Detailed Clinical Characterization. Thyroid. Published 11 June 2025. doi:10.
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