Prepubertal Children with Papillary Thyroid Carcinoma Present with More Invasive Disease Than Adolescents and Young Adults
Authors' conclusion
Patients aged <11 years old present with more advanced disease than adolescents, with a higher likelihood of nodal and distant metastatic disease at time of diagnosis, although survival is high.
Study context
- Population
- Pediatric and young adult papillary thyroid carcinomas (PTCs) diagnosed 2004–2017, National Cancer Database4,860 pediatric
- Participants
- 274 / 4,586 / 101,159
- Exposure
- Prepubertal vs adolescent vs young adult patients with PTC
- Prepubertaln = 274
- Adolescentn = 4,586
- Young adultn = 101,159reference
- Outcome
- Independent predictors of metastases (prepubertal age)
Methodological detailsNational Cancer Database, multivariable logistic regression
- National Cancer Database
- Multivariable logistic regression
Main finding
As reported in the abstract
Prepubertal vs Young adultAdjusted odds ratio (95% CI)P value
Positive regional nodes
1.36(1.01–1.84)
P = 0.04Distant metastatic disease
3.12(1.96–4.96)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | aOR (CI) | P value | |
|---|---|---|---|
| Lymph node metastases in microcarcinomas (≤10 mm), prepubertal agePrepubertalvs Young adult | 2.19 (1.10–4.36) | P = 0.03 | |
| 0.20.5125Adjusted odds ratio (log scale) |
| Outcome | P value |
|---|---|
| SurvivalBetween Prepubertal and Adolescent · no difference in survival between groups | P = 0.32 |
| Gross ETE with primary tumors ≤1 cm, prepubertal (n = 41) vs adolescent (n = 937)Prepubertal age associated with gross ETE | P = 0.004 |
Original publication
Prepubertal Children with Papillary Thyroid Carcinoma Present with More Invasive Disease Than Adolescents and Young Adults. Thyroid. Published 9 December 2022. doi:10.
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