Association of Body Mass Index With Clinicopathological Features of Papillary Thyroid Carcinoma: A Retrospective Study
Authors' conclusion
Overweight and obesity were significantly associated with aggressive clinicopathological features of PTC and PTMC. The impact of overweight and obesity should be considered when choosing treatment decisions for PTC and PTMC.
Study context
- Population
- Patients with papillary thyroid carcinoma (PTC) who underwent surgical treatment
- Participants
- 4,476 patients
- Exposure
- Overweight and obese vs normal weight
- Outcome
- Clinicopathological features of PTC
Methodological detailsmultivariate binary logistic regression
- Multivariate binary logistic regression
Main finding
As reported in the abstract
- Overweight · bilaterality
- OR 1.295; P < 0.05 for all
- Obese · bilaterality
- OR 1.669; P < 0.05 for all
- Overweight · multifocality
- OR 1.273; P < 0.05 for all
- Obese · multifocality
- OR 1.617; P < 0.05 for all
- Overweight · extrathyroidal extension
- OR 1.560; P < 0.05 for all
- Obese · extrathyroidal extension
- OR 2.477; P < 0.05 for all
- Overweight · T (3 + 4) stage
- OR 1.482; P < 0.05 for all
- Obese · T (3 + 4) stage
- OR 2.392; P < 0.05 for all
- Overweight · intermediate-high recurrence risk
- OR 1.215; P < 0.05 for all
- Obese · intermediate-high recurrence risk
- OR 1.718; P < 0.05 for all
- Correlation between body mass index (BMI) and PTC tumor size (Spearman r)
- r = 0.087, P < .001
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| Clinicopathological features in papillary thyroid microcarcinoma (PTMC)Overweight vs Normal weight · bilaterality | 1.341 | P < 0.05 for all |
| Clinicopathological features in papillary thyroid microcarcinoma (PTMC)Obese vs Normal weight · bilaterality | 1.737 | P < 0.05 for all |
| Clinicopathological features in papillary thyroid microcarcinoma (PTMC)Overweight vs Normal weight · multifocality | 1.244 | P < 0.05 for all |
| Clinicopathological features in papillary thyroid microcarcinoma (PTMC)Obese vs Normal weight · multifocality | 1.640 | P < 0.05 for all |
| Clinicopathological features in papillary thyroid microcarcinoma (PTMC)Overweight vs Normal weight · extrathyroidal extension | 1.992 | P < 0.05 for all |
| Clinicopathological features in papillary thyroid microcarcinoma (PTMC)Obese vs Normal weight · extrathyroidal extension | 2.080 | P < 0.05 for all |
| Clinicopathological features in papillary thyroid microcarcinoma (PTMC)Overweight vs Normal weight · T (3 + 4) stage | 1898 | P < 0.05 for all |
| Clinicopathological features in papillary thyroid microcarcinoma (PTMC)Obese vs Normal weight · T (3 + 4) stage | 2.039 | P < 0.05 for all |
| Clinicopathological features in papillary thyroid microcarcinoma (PTMC)Overweight vs Normal weight · intermediate-high recurrence risk | 1.458 | P < 0.05 for all |
| Clinicopathological features in papillary thyroid microcarcinoma (PTMC)Obese vs Normal weight · intermediate-high recurrence risk | 1.536 | P < 0.05 for all |
Original publication
Association of Body Mass Index With Clinicopathological Features of Papillary Thyroid Carcinoma: A Retrospective Study. Endocr Pract. Published 5 December 2022. doi:10.
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