Limitations of fine‐needle aspiration and core needle biopsies in the diagnosis of tall cell variant of papillary thyroid carcinoma
Authors' conclusion
Both cytomorphologic features in FNA and the percentage of tall cells in CNB present limitations for use as accurate preoperative diagnostic tools of TCV-PTC.
Study context
- Population
- Adults diagnosed with tall cell variant papillary thyroid carcinoma (TCV-PTC) or PTC with tall cell features at final surgical pathology, January 2015–December 2018
- Participants
- 119 adults
- Exposure
- Preoperative fine-needle aspiration (FNA) cytomorphology and core needle biopsy (CNB) tall-cell percentage vs final surgical pathology for TCV-PTC
- PTC with tall cell features (TCF)n = 35reference
- Outcome
- Whether FNA (six cytomorphologic features suggesting TCV-PTC) or CNB (percentage of tall cells) could diagnose TCV-PTC preoperatively
Main finding
As reported in the abstract
- Most frequent FNA cytomorphological feature in TCV-PTC: tall columnar cells, incl. single tombstone-like cells
- 70%
- TCV-PTC evaluated by FNA
- 43
- FNA with none of the six cytomorphologic features suggesting TCV-PTC
- 3 (7%)
- TCV-PTC detected preoperatively by CNB with 30% tall-cell cutoff
- 16 (41%)
- TCV-PTC without any tall cells on CNB
- 3 (7%)
Observational data: associations, not effects.
Original publication
Limitations of fine‐needle aspiration and core needle biopsies in the diagnosis of tall cell variant of papillary thyroid carcinoma. Clin Endocrinol (Oxf). Published 17 April 2022. doi:10.
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