Predictors of treatment response in lymphogenic metastasized papillary thyroid cancer: a histopathological study
Authors' conclusion
Detailed reexamination of lymph nodes revealed that only the presence of more than 5 lymph node metastases was an independent predictor of failure to achieve a complete response to treatment. No predictive value was found for other histopathological features, including the diameter of the lymph node metastases. These findings have the potential to improve risk stratification in patients with PTC and clinically evident lymph node metastases.
Study context
- Population
- Papillary thyroid cancer (PTC) patients with clinically evident lymph node metastases1,042 lymph node metastases
- Participants
- 129 patients
- Exposure
- >5 lymph node metastases vs ≤5
- Outcome
- Failure to achieve a complete biochemical and structural response to treatment
Methodological detailspredefined reexamination protocol
- Predefined reexamination protocol
Main finding
As reported in the abstract
Failure to achieve complete response to treatment
- More than 5 lymph node metastases: only independent predictor, OR 3.39 (95% CI 1.57-7.33), P < .05
- Diameter nor any of the other evaluated lymph node features (extranodal extension, cystic changes, necrosis, calcifications, proportion of node taken up by tumor) were significantly associated with response to treatment
Observational data: associations, not effects.
Original publication
Predictors of treatment response in lymphogenic metastasized papillary thyroid cancer: a histopathological study. Eur J Endocrinol. Published 23 April 2024. doi:10.
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