Feasibility of active surveillance in patients with clinically T1b papillary thyroid carcinoma ≤1.5 cm in preoperative ultrasonography: MASTER study
Authors' conclusion
For PTC patients aged 55 years or older with cT1b≤1.5, AS could be a viable option due to the absence of a significant relationship between tumor size and occult central LN.
Study context
- Population
- Clinically T1N0 patients with preoperative US information, from a cohort of 1259 patients who underwent lobectomy and were finally diagnosed with papillary thyroid carcinoma (PTC), June 2020 to March 2022from cohort of 1259
- Participants
- 935 patients
- Exposure
- cT1b≤1.5 vs cT1a PTC by tumor size group
- cT1an = 719reference
- cT1b≤1.5n = 171
- Outcome
- Lymphatic invasion, occult central LN metastasis and metastatic LN ratio
Main finding
As reported in the abstract
- cT1b≤1.5 had more lymphatic invasion and occult central lymph node (LN) metastasis, with a higher metastatic LN ratio, than cT1a
Observational data: associations, not effects.
Further findings
Occult central LN metastasis and metastatic LN ratio, patients aged ≥55 years
- No significant differences between cT1a, cT1b≤1.5 and cT1b>1.5
Factors associated with occult central LN metastasis (multivariate regression)
- Age <55: associated with age, sex, tumor size, extrathyroidal extension and lymphatic invasion
- Age ≥55: associated only with age and lymphatic invasion
Original publication
Feasibility of active surveillance in patients with clinically T1b papillary thyroid carcinoma ≤1.5 cm in preoperative ultrasonography: MASTER study. Eur Thyroid J. Published 18 April 2024. doi:10.
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