A Prospective Cohort Study Exploring the Effect of Lenvatinib Planned Drug Holidays in Treatment of Differentiated Thyroid Cancer
Authors' conclusion
Planned drug holidays for lenvatinib were associated with significantly improved clinical outcomes compared to daily oral administration.
Study context
- Population
- Patients with unresectable RR-DTC treated with lenvatinib 24 mg daily orally in the COLLECT study253 evaluable for efficacy
- Participants
- 262 patients
- Comparison
- Lenvatinib with planned drug holidays vs without
- Planned drug holidayn = 73
Methodological detailsreal-world clinical setting
- Real-world clinical setting
Primary result
As reported in the abstract
OS, TTF, TFS and PFS
1-year overall survival (OS) with planned drug holiday
95.8%
1-year progression-free survival (PFS) with planned drug holiday
94.5%
Further findings
Duration of administration at dose ≥10 mg
- Significantly longer with planned drug holiday
Original publication
A Prospective Cohort Study Exploring the Effect of Lenvatinib Planned Drug Holidays in Treatment of Differentiated Thyroid Cancer. Thyroid. Published 17 April 2024. doi:10.
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