Predictors of Diabetes Outcomes at 1 Year After Islet Autotransplantation: Data From a Multicenter Cohort Study
Authors' conclusion
Patients with normoglycemia and children more often were off insulin. In multivariable models, pre-TPIAT HbA1c was strongly predictive of insulin independence, islet function, and HbA1c <7% at 1 year.
Study context
- Population
- Patients with intractable recurrent acute or chronic pancreatitis who underwent total pancreatectomy with islet autotransplantation (TPIAT), enrolled in Prospective Observational Study of TPIAT (POST); mean age 29.6 years, 61.7% female
- Participants
- 384 patients
- Outcome
- Diabetes outcomes: insulin use, HbA1c and islet graft function
- Follow-up
- 1 year post-TPIAT
Methodological detailsprospective observational
- Prospective observational
Main finding
As reported in the abstract
Diabetes outcomes post-TPIAT · 1 year
Retained islet function (C-peptide >0.3 ng/mL)
83%
Off insulin
20%
HbA1c <7%
60%
Observational data: associations, not effects.
Further findings
| Outcome | OR | |
|---|---|---|
| Predictors of insulin independence at 1 year (multivariable)Pediatric agevs Adults | 2.3 (95% CI 1.3–4.3) | |
| Predictors of insulin independence at 1 year (multivariable)Pretransplant HbA1c, per 1% decrease | 4.0 (95% CI 1.7–9.1) | |
| Predictors of HbA1c <7% at 1 year (multivariable)Pre-TPIAT HbA1c, per 1% decrease | 2.2 (CI 1.1–4.3) | |
| Predictors of islet graft function at 1 year (multivariable)Pre-TPIAT fasting C-peptide, per 1 ng/mL increase | 2.18 (CI 1.42–3.35) | |
| Predictors of islet graft function at 1 year (multivariable)Baseline HbA1c, per 1% decrease | 1.89 (CI 1.18–3) | |
| 0.10.31310Odds ratio (log scale) |
Predictors of HbA1c <7% at 1 year (multivariable)
| OR (CI) | ||
|---|---|---|
| White race | 4.3 (1.7–11) | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Predictors of Diabetes Outcomes at 1 Year After Islet Autotransplantation: Data From a Multicenter Cohort Study. Diabetes Care. Published 9 July 2025. doi:10.
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