Islet Autoantibodies and Their Association With β-Cell Function and Diabetes Measures in Children With Acute Recurrent and Chronic Pancreatitis
Authors' conclusion
In children with ARP or CP, Ab+ was associated with higher risk of diabetes/diabetes development and shorter time to diabetes development, suggesting that islet Ab+ is associated with β-cell dysfunction in this patient cohort. Islet Ab+ was also associated with higher HbA1c and lower C-peptide levels. Future studies are needed to validate the role of islet Ab positivity in pancreatitis.
Study context
- Population
- Youth with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP) who had islet Ab testingMixed meal tolerance testing (MMTT) in 183
- Participants
- 234 participants
- Exposure
- Islet autoantibody positive vs negative
- Ab+n = 28
- Ab-n = 206reference
- Outcome
- Prediabetes/diabetes
Main finding
As reported in the abstract
P < 0.001
- Islet Ab prevalence
- 12%
Observational data: associations, not effects.
Further findings
HbA1c
P < 0.01
C-peptide (MMTT)
P = 0.01
- Time from first acute pancreatitis episode to diabetes · shorter with Ab+ · survival analysis
- P = 0.02
Number of islet Ab among Ab+
- One Ab
- 54%
- Multiple Ab
- 46%
Age, sex, race, ethnicity, BMI percentile, fasting glucose
- Did not differ between Ab+ and Ab-
Original publication
Islet Autoantibodies and Their Association With β-Cell Function and Diabetes Measures in Children With Acute Recurrent and Chronic Pancreatitis. Diabetes Care. Published 15 April 2025. doi:10.
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