Empagliflozin in Patients With Type 2 Diabetes Undergoing On-Pump Coronary Artery Bypass Grafting (CABG): The POST-CABGDM Randomized Clinical Trial
Primary result · Postoperative AKIResult — go to the resultRelative risk 0.57 95% CI 0.34–0.96Authors' conclusion
Empagliflozin use before on-pump CABG in patients with T2DM was associated with a reduced incidence of postoperative AKI without an increase in safety events. These findings warrant confirmation in larger clinical trials.
Study context
- Population
- Patients with T2D scheduled for elective on-pump CABG, Brazilrandomized
- Participants
- 145 patients
- Comparison
- Empagliflozin 25 mg daily plus standard care vs standard care alone
- Empagliflozinn = 71
- Standard caren = 74reference
- Primary endpoint
- Postoperative acute kidney injury (AKI) by creatinine-based criteria (AKIN, RIFLE or KDIGO)
- Follow-up
- Within 7 days of surgery
Methodological detailsinvestigator-initiated, pragmatic, single-centre, open-label, blinded outcome adjudication
- Investigator-initiated
- Pragmatic
- Single-centre
- Open-label
- Blinded outcome adjudication
Primary result
Postoperative AKI
Relative risk
0.57
95% CI 0.34–0.96
P = 0.03
By group
Empagliflozinvs Standard care
RR 0.57 (95% CI 0.34–0.96); P = 0.03
As reported in the abstract
Secondary outcomes
30-day postoperative AF
- Rates of AF similar between groups (15.4% vs. 13.5%)
- RR 1.15 (95% CI 0.52-2.53); P = 0.73
30-day type 5 myocardial infarction (MI)
- Rates of type 5 MI similar between groups (1.4% vs. 4.1%)
- RR 0.35 (95% CI 0.04-3.26); P = 0.62
Deaths
- Deaths, all in the control group
- 3
Safety
Safety events (ketoacidosis, UTI, hospital-acquired pneumonia, wound infection) · within 30 days after CABG
- No statistically significant differences between groups for safety events
Original publication
Empagliflozin in Patients With Type 2 Diabetes Undergoing On-Pump CABG: The POST-CABGDM Randomized Clinical Trial. Diabetes Care. Published 15 April 2025. doi:10.
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