Degree of islet function preservation and continuous glucose monitoring in individuals undergoing total pancreatectomy with islet autotransplantation
Authors' conclusion
Nearly half of islet secretory function is retained after TPIAT.
Study context
- Population
- Individuals undergoing TPIAT from 2014 to 2024; 88.5% chronic pancreatitis; at baseline 57.7% prediabetes or diabetes, 46.2% previous pancreatic surgery
- Participants
- 26 individuals
- Outcome
- Islet secretory function (C-peptide AUC on 2 h liquid meal stimulation test) relative to baseline
- Follow-up
- 3 months post TPIAT
Methodological detailsEligibility for TPIAT assessed by a multidisciplinary team
- Eligibility for TPIAT assessed by a multidisciplinary team
Main finding
As reported in the abstract
Islet secretory function (C-peptide AUC), % of baseline
C-peptide AUC as % of baseline
45%
Observational data: associations, not effects.
Further findings
TIR (CGM) · 3 months
- TIR, mean ± SD
- 75.2 ± 26.1%
- TIR positively correlated with C-peptide AUC
- P < 0.0001
Islet function after 3 months
- Islet function did not significantly change; stable BETA-2 score
Original publication
Degree of islet function preservation and continuous glucose monitoring in individuals undergoing total pancreatectomy with islet autotransplantation. Diabetologia. Published 27 June 2026. doi:10.
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