Accuracy of Two Continuous Glucose Monitors Differs after Hydroxyurea in Pediatric Patients Undergoing Total Pancreatectomy with Islet Autotransplantation
Authors' conclusion
Hydroxyurea does not seem to interfere with the accuracy of Libre in contrast to Dexcom.
Study context
- Population
- Pediatric patients undergoing total pancreatectomy with islet autotransplantation (TPIAT), wearing both continuous glucose monitors (CGMs) from approximately a week after TPIAT560 time points
- Participants
- 7 patients
- Comparison
- Dexcom CGM vs Libre CGM, after hydroxyurea and at other times
- Outcome
- CGM accuracy in the 9 h after hydroxyurea
- Follow-up
- 9 h after hydroxyurea
Methodological detailspaired measurements vs POCT BG, Clarke error grids, Wilcoxon-Mann-Whitney tests, two-sided P < 0.05
- Paired measurements vs POCT BG
- Clarke error grids
- Wilcoxon-Mann-Whitney tests, two-sided P < 0.05
Performance
As reported in the abstract
CGM accuracy in the 9 h after hydroxyurea
MARD Dexcom 59.5% · Libre 14.8%
Median absolute difference vs POCT BG Dexcom 56 mg/dL [32-88] · Libre 12 mg/dL [6-23]
Clarke Zones A/B Dexcom 77.9% · Libre 98.3%
- Dexcom vs Libre: P < 0.001
- Dexcom vs Libre: P < 0.001 — greater with Dexcom
Further findings
CGM accuracy at all other times
P < 0.001
MARD Dexcom 19.8% · Libre 14.7%
Median absolute difference vs POCT BG Dexcom 18 mg/dL [9-30] · Libre 13 mg/dL [6-23]
| Outcome | P value |
|---|---|
| CGM accuracy at all other timesClinically similar | P < 0.001 |
Original publication
Accuracy of Two Continuous Glucose Monitors Differs after Hydroxyurea in Pediatric Patients Undergoing Total Pancreatectomy with Islet Autotransplantation. Diabetes Technol Ther. Published 18 March 2025. doi:10.
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