Gestational diabetes & diabetes in pregnancy
Predicting Preeclampsia in Gestational Diabetes Mellitus Using the sFlt-1/PlGF Ratio
Authors' conclusion
The results of this investigation indicate that although GDM may lead to changes in the sFlt-1/PlGF ratio, the sFlt-1/PlGF ratio test retains its clinical utility in predicting PE onset.
Study context
- Population
- Pregnant women with and without gestational diabetes mellitus (GDM), and with and without PE, Royal Women's Hospital, Melbourne, Australia, September 2016–September 20221,416 ratio results
- Comparison
- sFlt-1/PlGF ratio performance for PE prediction in women with vs without GDM
- Outcome
- sFlt-1, PlGF and sFlt-1/PlGF ratio test results in relation to PE and GDM
Methodological detailssingle-centre
- Single-centre
Performance
As reported in the abstract
sFlt-1/PlGF ratio prediction of PE · 0 to 7 days before delivery
| Test or model | AUC | Sensitivity | NPV |
|---|---|---|---|
| PE + No GDM | 0.82 (95% CI 0.79-0.87) | 85.3% (95% CI 80.8-89.1%)Sensitivity on a scale from 0 to 100 percent | 92.7% (95% CI 90.5-94.5%) |
| PE + GDM | 0.87 (95% CI 0.82-0.93) | 89.4% (95% CI 76.9-96.5%)Sensitivity on a scale from 0 to 100 percent | 94.8% (95% CI 88.7-97.7%) |
AUC
PE + No GDM0.82 (95% CI 0.79-0.87)
PE + GDM0.87 (95% CI 0.82-0.93)
Sensitivity
PE + No GDM85.3% (95% CI 80.8-89.1%)
PE + GDM89.4% (95% CI 76.9-96.5%)
Sensitivity on a scale from 0 to 100 percentNPV
PE + No GDM92.7% (95% CI 90.5-94.5%)
PE + GDM94.8% (95% CI 88.7-97.7%)
Original publication
Predicting Preeclampsia in Gestational Diabetes Mellitus Using the sFlt-1/PlGF Ratio. J Clin Endocrinol Metab. Published 4 February 2025. doi:10.
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